Sphingosine 1-phosphate: a prototype of a new class of second messengers.

@article{Spiegel1999Sphingosine1A,
  title={Sphingosine 1-phosphate: a prototype of a new class of second messengers.},
  author={Sarah Spiegel},
  journal={Journal of leukocyte biology},
  year={1999},
  volume={65 3},
  pages={341-4}
}
Sphingosine 1-phosphate (SPP) is an important sphingolipid-derived second messenger in mammalian cells that acts to promote proliferation and to inhibit apoptosis. Various growth factors increase the intracellular concentration of SPP by activating sphingosine kinase, the molecular cloning of which has revealed that it defines a new type of lipid kinase. Cell fate is influenced by the balance between the intracellular concentration of SPP and that of ceramide, a pro-apoptotic sphingolipid… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 52 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 41 references

Similar Papers

Loading similar papers…