Sphingosine-1-phosphate: a potential therapeutic agent against human breast cancer

  title={Sphingosine-1-phosphate: a potential therapeutic agent against human breast cancer},
  author={Binbing Ling and Lifeng Chen and Jane Alcorn and Baohua Ma and Jian Yang},
  journal={Investigational New Drugs},
Sphingosine-1-phosphate (S1P) is an important regulator of cancer development and progression. Its cellular concentration is controlled predominantly by sphingosine kinase (SK) and sphingosine-1-phosphate lyase (SPL). In the current study we showed that mRNA expressions for both SK and SPL were up-regulated throughout all four disease stages in human breast cancer patients. Exogenous administration of S1P produced a bell-shaped dose response for apoptosis in normal mammary gland MCF12A cells… CONTINUE READING

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