Sphingosine-1-phosphate: a potential therapeutic agent against human breast cancer

@article{Ling2009Sphingosine1phosphateAP,
  title={Sphingosine-1-phosphate: a potential therapeutic agent against human breast cancer},
  author={Binbing Ling and Lifeng Chen and Jane Alcorn and Baohua Ma and Jian Yang},
  journal={Investigational New Drugs},
  year={2009},
  volume={29},
  pages={396-399}
}
Sphingosine-1-phosphate (S1P) is an important regulator of cancer development and progression. Its cellular concentration is controlled predominantly by sphingosine kinase (SK) and sphingosine-1-phosphate lyase (SPL). In the current study we showed that mRNA expressions for both SK and SPL were up-regulated throughout all four disease stages in human breast cancer patients. Exogenous administration of S1P produced a bell-shaped dose response for apoptosis in normal mammary gland MCF12A cells… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-9 of 9 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 26 references

Sphingosine-1-phosphate lyase potentiates apoptosis via p53- and p38-dependent pathways and is down-regulated in colon cancer.

Proceedings of the National Academy of Sciences of the United States of America • 2006
View 1 Excerpt

Taxanes and COX-2 inhibitors: from molecular pathways to clinical practice.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie • 2005
View 1 Excerpt

Similar Papers

Loading similar papers…