Sphingosine-1-phosphate: a platelet-activating sphingolipid released from agonist-stimulated human platelets.

@article{Yatomi1995Sphingosine1phosphateAP,
  title={Sphingosine-1-phosphate: a platelet-activating sphingolipid released from agonist-stimulated human platelets.},
  author={Yutaka Yatomi and Fei Ruan and Sen-ichiroh Hakomori and Yasuyuki Igarashi},
  journal={Blood},
  year={1995},
  volume={86 1},
  pages={193-202}
}
Sphingosine-1-phosphate (Sph-1-P) is the initial product of catabolism of sphingosine by sphingosine kinase and is cleaved by Sph-1-P lyase to a fatty aldehyde and ethanolamine phosphate. This phosphorylated sphingoid base is not only an intermediary catabolite, but also a bioactive lipid with important functions, including stimulation of cell proliferation in Swiss 3T3 fibroblasts and inhibition of tumor cell motility. In the present study, we examined functional roles of Sph-1-P in human… CONTINUE READING