Sphingosine-1-phosphate: a Missing Cofactor for the E3 Ubiquitin Ligase Traf2

  title={Sphingosine-1-phosphate: a Missing Cofactor for the E3 Ubiquitin Ligase Traf2},
  author={Sergio E. Alvarez and Kuzhuvelil B Harikumar and Nitai C Hait and Jeremy C. Allegood and Graham M. Strub and Eugene Kim and Michael W Maceyka and Hualiang Jiang and Cheng Luo and Tomasz Kordula and Sheldon Milstien and Sarah Spiegel},
Tumour-necrosis factor (TNF) receptor-associated factor 2 (TRAF2) is a key component in NF-κB signalling triggered by TNF-α. Genetic evidence indicates that TRAF2 is necessary for the polyubiquitination of receptor interacting protein 1 (RIP1) that then serves as a platform for recruitment and stimulation of IκB kinase, leading to activation of the transcription factor NF-κB. Although TRAF2 is a RING domain ubiquitin ligase, direct evidence that TRAF2 catalyses the ubiquitination of RIP1 is… CONTINUE READING
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