Sphingosine-1-phosphate/sphingosine kinase pathway is involved in mouse airway hyperresponsiveness.

  title={Sphingosine-1-phosphate/sphingosine kinase pathway is involved in mouse airway hyperresponsiveness.},
  author={Fiorentina Roviezzo and Annarita Di Lorenzo and Mariarosaria Bucci and Vincenzo Brancaleone and Valentina Vellecco and Marilisa De Nardo and Donatella Orlotti and Raffaele De Palma and Francesco Mattia Rossi and Bruno D'Agostino and Giuseppe Antonio Cirino},
  journal={American journal of respiratory cell and molecular biology},
  volume={36 6},
Sphingosine-1-phosphate (S1P) has been shown to regulate numerous and diverse cell functions, including smooth muscle contraction. Here we assessed the role of S1P/Sphingosine kinase (SPK) pathway in the regulation of bronchial tone. Our objective was to determine, using an integrated pharmacologic and molecular approach, (1) the role of S1P as endogenous modulator of the bronchial tone, and (2) the linkage between S1P pathway and bronchial hyperresponsiveness. We evaluated S1P effects on… CONTINUE READING


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