Sphingosine 1-phosphate/sphingosine 1-phosphate receptor 1 signaling in rheumatoid synovium: regulation of synovial proliferation and inflammatory gene expression.

@article{Kitano2006Sphingosine11,
  title={Sphingosine 1-phosphate/sphingosine 1-phosphate receptor 1 signaling in rheumatoid synovium: regulation of synovial proliferation and inflammatory gene expression.},
  author={Masayasu Kitano and Timothy Hla and Masahiro Sekiguchi and Yutaka Kawahito and Rikio Yoshimura and Keiji Miyazawa and Tsuyoshi Iwasaki and Hajime Sano and Julie D Saba and Yuen Yee Tam},
  journal={Arthritis and rheumatism},
  year={2006},
  volume={54 3},
  pages={
          742-53
        }
}
OBJECTIVE Sphingosine 1-phosphate (S1P) is involved in various pathologic conditions and has been implicated as an important mediator of angiogenesis, inflammation, cancer, and autoimmunity. This study was undertaken to examine the role of S1P/S1P1 signaling in the pathogenesis of rheumatoid arthritis (RA). METHODS We examined S1P1 messenger RNA (mRNA) and protein levels in RA synoviocytes and MH7A cells by reverse transcriptase-polymerase chain reaction and Western blotting. We also… Expand
Sphingosine kinase 1/sphingosine 1-phosphate/sphingosine 1-phosphate receptor 1 pathway: A novel target of geniposide to inhibit angiogenesis.
TLDR
Geniposide reduces the activity of SphK1 by restoring the dynamic balance between pro/anti-angiogenic factors, thereby interfering with SphK 1-S1P-S 1PR1 signal transduction, reducing the formation of synovial microvessels and exerting anti-angIogenesis effect of RA. Expand
Upregulation of sphingosine-1-phosphate receptor 3 on fibroblast-like synoviocytes is associated with the development of collagen-induced arthritis via increased interleukin-6 production
TLDR
It is demonstrated that S 1P3 expression is associated with the development of autoimmune arthritis via inflammation-induced increases in S1P/S1P3 signaling that increase production of IL-6 in FLSs. Expand
Sphingosine 1-Phosphate Counteracts the Effects of Interleukin-1β in Human Chondrocytes
TLDR
S1P2 was identified as the most prevalent S1P receptor subtype in human OA cartilage and chondrocytes in vitro and Activation of the S1p2 receptor counteracts the detrimental phosphorylation of p38 MAPK by IL-1β. Expand
Anti-Inflammatory Effects of Sphingosine Kinase Modulation in Inflammatory Arthritis1
TLDR
Results demonstrate SphK modulation may provide a novel approach in treating chronic autoimmune conditions such as RA by inhibiting the release of pro-inflammatory cytokine production in response to type II collagen in vitro. Expand
Metastasis-associated protein 1 (MTA1) signaling in rheumatoid synovium: Regulation of inflammatory response and cytokine-mediated production of prostaglandin E2 (PGE2).
TLDR
Exchange level of Metastasis associated protein 1 (MTA1), an important chromatin modifier that plays a critical role in transcriptional regulation by modifying DNA accessibility for cofactors, was upregulated in human rheumatoid synovial tissues and points to its indispensable role in the modulation of the integrated cytokine network along the pathogenesis of RA. Expand
Decreased Expression of Sphingosine-1-Phosphate Receptor 1 in the Blood Leukocyte of Rheumatoid Arthritis Patients
TLDR
The level of S1P1 mRNA expression in the blood leukocytes of RA patients was investigated and, in contrast to the previous reports, the expression level of this gene was not correlated to their clinical scores, disease durations and ages. Expand
Specific and overlapping sphingosine-1-phosphate receptor functions in human synoviocytes: impact of TNF-alpha.
TLDR
The data suggest that S1P(1), S2P(2), and S3P(3) play essential roles in the pathogenesis of RA by modulating FLS migration, cytokine/chemokine production, and cell survival. Expand
Chemical Hypoxia Brings to Light Altered Autocrine Sphingosine-1-Phosphate Signalling in Rheumatoid Arthritis Synovial Fibroblasts
TLDR
The results suggest that the sphingolipid pathway regulating the intracellular levels of S1P is dysregulated in RAFLS and has a significant impact on cell autocrine activation by S1F, raising the issue of synovial cell burnout due to chronic inflammation. Expand
Sphingosine kinase and sphingosine-1-phosphate receptors: novel therapeutic targets of rheumatoid arthritis?
TLDR
The results clearly demonstrate that such anti- and proinflammatory potential of SphK1/2 modulation may alter the outcome in RA synovitis and raises the possibility that drugs that specifically target SphK 1 activity may play a beneficial role in the treatment of RA and other autoimmune rheumatic diseases. Expand
Spingosine-1-phosphate stimulates proliferation and counteracts interleukin-1 induced nitric oxide formation in articular chondrocytes.
TLDR
S1P significantly reduced NO formation and iNOS mRNA and protein expression, both in un-stimulated and IL-1beta stimulated bovine chondrocytes, and suggests that S1P provides an anti-catabolic signal in articular chondroses. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 51 REFERENCES
Cyclooxygenase-1 and -2 expression in rheumatoid synovial tissues. Effects of interleukin-1 beta, phorbol ester, and corticosteroids.
TLDR
Modulation of Cox-2 expression by IL-1 beta and corticosteroids may be an important component of the inflammatory process in synovial tissues from patients with RA. Expand
Feedback control of the arachidonate cascade in rheumatoid synoviocytes by 15-deoxy-Delta(12,14)-prostaglandin J2.
TLDR
15d-PGJ2, but not TRO and other prostanoids, suppressed interleukin (IL)-1beta-induced PGE2 synthesis in rheumatoid synovial fibroblasts (RSFs) through the inhibition of cyclooxygenase (COX-2) and cytosolic phospholipase A2 (cPLA2) expression, providing new insight into the feedback mechanism of the arachidonate cascade. Expand
Interleukin‐1α and tumor necrosis factor α synergistically stimulate prostaglandin E2‐dependent production of interleukin‐11 in rheumatoid synovial fibroblasts
TLDR
It is suggested that IL-1alpha and TNFalpha synergistically stimulate the production of IL-11 via their effects on PGE2 production in the rheumatoid joint, and that atypical PKC may be another target for down-regulation of IL -11, the bone resorption-associated cytokine. Expand
Coexpression of microsomal prostaglandin E synthase with cyclooxygenase-2 in human rheumatoid synovial cells.
TLDR
The results suggest that abundant PGE2 production at inflammation sites such as rheumatoid synovia is caused by the coordinated upregulation of mPGES and COX-2. Expand
Coexpression of phosphotyrosine-containing proteins, platelet-derived growth factor-B, and fibroblast growth factor-1 in situ in synovial tissues of patients with rheumatoid arthritis and Lewis rats with adjuvant or streptococcal cell wall arthritis.
TLDR
The data suggest that FGF-1 and PDGF-B-like factors are upregulated and may induce tyrosine phosphorylation of proteins in vivo in inflammatory joint diseases, and persistent high level P-Tyr expression is T lymphocyte dependent, correlates with disease severity, and is strain dependent in rats. Expand
Physiological and pathological actions of sphingosine 1-phosphate.
  • T. Hla
  • Biology, Medicine
  • Seminars in cell & developmental biology
  • 2004
TLDR
The ubiquity of the mediator and its receptors, as well as the evolutionary conservation of S1P metabolism and action, argues that it is a potent and ubiquitous physiological factor in many contexts, and warrant a fuller understanding of its actions at the molecular, cellular and organismal levels. Expand
Sphingosine 1-Phosphate in Amniotic Fluid Modulates Cyclooxygenase-2 Expression in Human Amnion-derived WISH Cells*
TLDR
It is found that lipid components dissolved in the amniotic fluid modulate PG synthesis in WISH human amnion cells and one of these components is identified as a sphingosine 1-phosphate (S1P). Expand
Antiproliferative Properties of Sphingosine 1-Phosphate in Human Hepatic Myofibroblasts
TLDR
Light is shed on a novel role for S1P as a growth inhibitory mediator and its potential involvement in the negative regulation of liver fibrogenesis and delayed COX-2 induction is pointed out. Expand
Sphingosine 1-phosphate receptors.
  • T. Hla
  • Chemistry, Medicine
  • Prostaglandins & other lipid mediators
  • 2001
TLDR
Recent findings have shown that a family of G-protein-coupled receptors of the endothelial differentiation gene (EDG) family serve as plasma membrane-localized receptors for SPP, and these data strongly suggest that a physiological role of SPP is in the formation of the cardiovascular system. Expand
Sphingosine‐1‐phosphate induces proliferation of astrocytes: regulation by intracellular signalling cascades
TLDR
Observations show that astrocytes are targets for S1P, and their proliferation in response to S1p could have physiopathological consequences at sites of brain lesions and alterations of the blood–brain barrier. Expand
...
1
2
3
4
5
...