Sphingosine 1-Phosphate Receptors Mediate the Lipid-Induced cAMP Accumulation through Cyclooxygenase-2/Prostaglandin I2 Pathway in Human Coronary Artery Smooth Muscle Cells

@article{Damirin2005Sphingosine1R,
  title={Sphingosine 1-Phosphate Receptors Mediate the Lipid-Induced cAMP Accumulation through Cyclooxygenase-2/Prostaglandin I2 Pathway in Human Coronary Artery Smooth Muscle Cells},
  author={Alatangaole Damirin and Hideaki Tomura and Mayumi Komachi and Masayuki Tobo and Koichi Sato and Chihiro Mogi and Hiromi Nochi and Koichi Tamoto and Fumikazu Okajima},
  journal={Molecular Pharmacology},
  year={2005},
  volume={67},
  pages={1177 - 1185}
}
Sphingosine 1-phosphate (S1P) has been shown to exert a variety of biological responses through extracellular specific receptors or intracellular mechanisms. In the present study, we characterized a signaling pathway of S1P-induced cAMP accumulation in human coronary artery smooth muscle cells (CASMCs). S1P induced biphasic cAMP accumulation composed of a short-term and transient response (a peak at 2.5 min) and a late and sustained response (∼4-6 h). The late phase of cAMP accumulation was… 

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