Sphingosine 1-Phosphate Receptor 1 (S1P1) Upregulation and Amelioration of Experimental Autoimmune Encephalomyelitis by an S1P1 Antagonist

@article{Cahalan2013Sphingosine1R,
  title={Sphingosine 1-Phosphate Receptor 1 (S1P1) Upregulation and Amelioration of Experimental Autoimmune Encephalomyelitis by an S1P1 Antagonist},
  author={S. Cahalan and P. Gonzalez-Cabrera and N. Nguyen and M. Guerrero and E. A. G. Cisar and Nora B. Leaf and Steven J Brown and E. Roberts and H. Rosen},
  journal={Molecular Pharmacology},
  year={2013},
  volume={83},
  pages={316 - 321}
}
Sphingosine 1-phosphate receptor 1 (S1P1) is a G protein–coupled receptor that is critical for proper lymphocyte development and recirculation. Agonists to S1P1 are currently in use clinically for the treatment of multiple sclerosis, and these drugs may act on both S1P1 expressed on lymphocytes and S1P1 expressed within the central nervous system. Agonists to S1P1 and deficiency in S1P1 both cause lymphocyte sequestration in the lymph nodes. In the present study, we show that S1P1 antagonism… Expand
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