Sphingosine 1-Phosphate Induces Neutrophil Chemoattractant IL-8: Repression by Steroids

  title={Sphingosine 1-Phosphate Induces Neutrophil Chemoattractant IL-8: Repression by Steroids},
  author={Md Mostafizur Rahman and Hatem Alkhouri and Francesca S. M. Tang and Wenchi Che and Qi Mu Ge and Alaina J Ammit},
  booktitle={PloS one},
The bioactive sphingolipid sphingosine 1-phosphate (S1P) is found in increased amounts in the airways of asthmatics. S1P can regulate airway smooth muscle functions associated with asthmatic inflammation and remodeling, including cytokine secretion. To date however, whether S1P induces secretion of an important chemokine responsible for neutrophilia in airway inflammation--IL-8--was unexplored. The aim of this study was to investigate whether S1P induces IL-8 gene expression and secretion to… CONTINUE READING
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Corticosteroids Inhibit S1P-Induced IL-6 Secretion From Human Airway Smooth Muscle via MKP-1-Mediated Repression of MSK1

  • W Che, J Parmentier, P Seidel, M Manetsch, EE Ramsay
  • Am J Respir Cell Mol Biol
  • 2013
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