Sphingosine-1-Phosphate Enhances Satellite Cell Activation in Dystrophic Muscles through a S1PR2/STAT3 Signaling Pathway

@inproceedings{Loh2012Sphingosine1PhosphateES,
  title={Sphingosine-1-Phosphate Enhances Satellite Cell Activation in Dystrophic Muscles through a S1PR2/STAT3 Signaling Pathway},
  author={Kenneth C. Loh and Weng-In Leong and Morgan E. Carlson and Babak Oskouian and Ashok Kumar and Henrik Fyrst and Meng Zhang and Richard L Proia and Eric P. Hoffman and Julie D Saba},
  booktitle={PloS one},
  year={2012}
}
Sphingosine-1-phosphate (S1P) activates a widely expressed family of G protein-coupled receptors, serves as a muscle trophic factor and activates muscle stem cells called satellite cells (SCs) through unknown mechanisms. Here we show that muscle injury induces dynamic changes in S1P signaling and metabolism in vivo. These changes include early and profound induction of the gene encoding the S1P biosynthetic enzyme SphK1, followed by induction of the catabolic enzyme sphingosine phosphate lyase… CONTINUE READING
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