Sphingosine-1-Phosphate (S1P) Impacts Presynaptic Functions by Regulating Synapsin I Localization in the Presynaptic Compartment

@article{Riganti2016Sphingosine1PhosphateI,
  title={Sphingosine-1-Phosphate (S1P) Impacts Presynaptic Functions by Regulating Synapsin I Localization in the Presynaptic Compartment},
  author={L. Riganti and F. Antonucci and M. Gabrielli and I. Prada and P. Giussani and P. Viani and F. Valtorta and E. Menna and M. Matteoli and C. Verderio},
  journal={The Journal of Neuroscience},
  year={2016},
  volume={36},
  pages={4624 - 4634}
}
Growing evidence indicates that sphingosine-1-P (S1P) upregulates glutamate secretion in hippocampal neurons. However, the molecular mechanisms through which S1P enhances excitatory activity remain largely undefined. The aim of this study was to identify presynaptic targets of S1P action controlling exocytosis. Confocal analysis of rat hippocampal neurons showed that S1P applied at nanomolar concentration alters the distribution of Synapsin I (SynI), a presynaptic phosphoprotein that controls… Expand
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