Sphingosine 1-Phosphate (S1P) Signaling and the Vasculature

  title={Sphingosine 1-Phosphate (S1P) Signaling and the Vasculature},
  author={Christian Waeber},
Discovered more than 100 years ago, the bioactive sphingolipid metabolite sphingosine 1-phosphate (S1P) was long believed to act as an intracellular second messenger, modulating many biological processes, including calcium mobilization, cell growth, differentiation, survival, motility, and cytoskeleton organization (1). The discovery that a protein whose… CONTINUE READING