Sphingosine‐1‐phosphate suppresses TLR‐induced CXCL8 secretion from human T cells

@article{Sharma2013Sphingosine1phosphateST,
  title={Sphingosine‐1‐phosphate suppresses TLR‐induced CXCL8 secretion from human T cells},
  author={Naveen Sharma and Ajay Suresh Akhade and Ayub Qadri},
  journal={Journal of Leukocyte Biology},
  year={2013},
  volume={93}
}
T cells produce a number of cytokines and chemokines upon stimulation with TLR agonists in the presence or absence of TCR signals. Here, we show that secretion of neutrophil chemoattractant CXCL8 from human T cell line Jurkat in response to stimulation with TLR agonists is reduced when cell stimulation is carried out in presence of serum. Serum does not, however, inhibit TCR‐activated secretion of CXCL8 nor does it down‐regulate TLR‐costimulated IL‐2 secretion from activated T cells. The… Expand
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