Sphingomyelinase stimulates oxidant signaling to weaken skeletal muscle and promote fatigue.


Sphingomyelinase (SMase) hydrolyzes membrane sphingomyelin into ceramide, which increases oxidants in nonmuscle cells. Serum SMase activity is elevated in sepsis and heart failure, conditions where muscle oxidants are increased, maximal muscle force is diminished, and fatigue is accelerated. We tested the hypotheses that exogenous SMase and accumulation of… (More)
DOI: 10.1152/ajpcell.00065.2010

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