Sphingomyelinase metabolites control survival and apoptotic death in SH-SY5Y neuroblastoma cells

@article{Tavarini2000SphingomyelinaseMC,
  title={Sphingomyelinase metabolites control survival and apoptotic death in SH-SY5Y neuroblastoma cells},
  author={Simona Tavarini and Laura Colombaioni and Mercedes Garcia-Gil},
  journal={Neuroscience Letters},
  year={2000},
  volume={285},
  pages={185-188}
}
There is increasing evidence that sphingolipids are involved in cell survival, differentiation or commitment to death. The effect of different sphingolipids and inhibitors of mitogen-activated protein kinase (MAPK) cascade on SH-SY5Y neuroblastoma cell death has been studied. Permeant ceramide analogues C2-Cer, C8-Cer, and C8-Cer-1-phosphate, but not dihydro C2-Cer induce apoptosis, as shown by Hoechst staining. Inhibition of ceramidase and sphingosine kinase, as well as incubation with… CONTINUE READING

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