Sphingomyelinase and membrane sphingomyelin content: determinants ofProximal tubule cell susceptibility to injury.

@article{Zager2000SphingomyelinaseAM,
  title={Sphingomyelinase and membrane sphingomyelin content: determinants ofProximal tubule cell susceptibility to injury.},
  author={Richard A Zager and Kristi M Burkhart and Ali C. M. Johnson},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2000},
  volume={11 5},
  pages={894-902}
}
Ceramides acutely accumulate in proximal tubules during injury. Pathogenic relevance of this change is suggested by observations that adding ceramide to tubular cells alters superimposed hypoxic and toxic attack. Ceramide accumulation during cell injury is thought to arise from sphingomyelinase (SMase)-mediated sphingomyelin (SM) hydrolysis +/- decreased catabolism. Thus, ceramide addition to cells cannot precisely simulate pathophysiologic events. Therefore, this study assessed direct effects… CONTINUE READING

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