Sphingomyelinase activity causes transbilayer lipid translocation in model and cell membranes.

  title={Sphingomyelinase activity causes transbilayer lipid translocation in model and cell membranes.},
  author={F. Xabier Contreras and A Villar and Alicia Alonso and Richard N. Kolesnick and F{\'e}lix M Go{\~n}i},
  journal={The Journal of biological chemistry},
  volume={278 39},
Ceramide is known to induce structural rearrangements in membrane bilayers, including the formation of ceramide-rich and -poor domains and the efflux of aqueous solutes. This report describes a novel effect of ceramide, namely the induction of transbilayer lipid movements. This effect was demonstrated in both model (large unilamellar vesicles) and cell (erythrocyte ghost) membranes in which ceramide generation took place in situ through the action of an externally added sphingomyelinase. Two… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 55 extracted citations

Dynamic transbilayer lipid asymmetry.

Cold Spring Harbor perspectives in biology • 2011
View 4 Excerpts
Highly Influenced


Publications referenced by this paper.

Antibodies: A Laboratory Manual

E. Harlow, D. Lane
July 10, • 1988

Similar Papers

Loading similar papers…