Sphingomyelin generated by sphingomyelin synthase 1 is involved in attachment and infection with Japanese encephalitis virus

@inproceedings{Taniguchi2016SphingomyelinGB,
  title={Sphingomyelin generated by sphingomyelin synthase 1 is involved in attachment and infection with Japanese encephalitis virus},
  author={M Taniguchi and Takafumi Tasaki and Hideaki Ninomiya and Yoshibumi Ueda and Koh-ichi Kuremoto and Susumu Mitsutake and Yasuyuki Igarashi and Toshiro Okazaki and Tsutomu Takegami},
  booktitle={Scientific reports},
  year={2016}
}
Japanese encephalitis virus (JEV) is a mosquito-borne RNA virus which infects target cells via the envelope protein JEV-E. However, its cellular targets are largely unknown. To investigate the role of sphingomyelin (SM) in JEV infection, we utilized SM-deficient immortalized mouse embryonic fibroblasts (tMEF) established from SM synthase 1 (SMS1)/SMS2 double knockout mice. SMS deficiency significantly reduced both intracellular and extracellular JEV levels at 48 h after infection. Furthermore… CONTINUE READING

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Comparative Analysis of Biological Sphingolipids with Glycerophospholipids and Diacylglycerol by LC-MS/MS

H Ogiso
Metabolites 4, • 2014

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