Sphingomyelin Functions as a Novel Receptor for Helicobacter pylori VacA

@article{Gupta2008SphingomyelinFA,
  title={Sphingomyelin Functions as a Novel Receptor for Helicobacter pylori VacA},
  author={Vijay R. Gupta and Hetal K. Patel and Sean S. Kostolansky and Roberto A. Ballivian and Joseph Eichberg and Steven Robert Blanke},
  journal={PLoS Pathogens},
  year={2008},
  volume={4},
  pages={1175 - 1186}
}
The vacuolating cytotoxin (VacA) of the gastric pathogen Helicobacter pylori binds and enters epithelial cells, ultimately resulting in cellular vacuolation. Several host factors have been reported to be important for VacA function, but none of these have been demonstrated to be essential for toxin binding to the plasma membrane. Thus, the identity of cell surface receptors critical for both toxin binding and function has remained elusive. Here, we identify VacA as the first bacterial virulence… CONTINUE READING