Sphingolipids are potential heat stress signals in Saccharomyces.

  title={Sphingolipids are potential heat stress signals in Saccharomyces.},
  author={Robert C. Dickson and E E Nagiec and Marek S. Skrzypek and Paul Tillman and Gregg B. Wells and Robert L. Lester},
  journal={The Journal of biological chemistry},
  volume={272 48},
The ability of organisms to quickly respond to stresses requires the activation of many intracellular signal transduction pathways. The sphingolipid intermediate ceramide is thought to be particularly important for activating and coordinating signaling pathways during mammalian stress responses. Here we present the first evidence that ceramide and other sphingolipid intermediates are signaling molecules in the Saccharomyces cerevisiae heat stress response. Our data show a 2-3-fold transient… CONTINUE READING


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Lipid Second Messengers

A.H.J. Merrill, D. C. Liotta, R. E. Riley
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