Sphingolipid synthesis and scavenging in the intracellular apicomplexan parasite, Toxoplasma gondii

@inproceedings{Pratt2013SphingolipidSA,
  title={Sphingolipid synthesis and scavenging in the intracellular apicomplexan parasite, Toxoplasma gondii},
  author={Steven E. Pratt and Nilu K. Wansadhipathi-Kannangara and Catherine R. Bruce and John G. M. Mina and Hosam Shams-Eldin and Josefina Casas and Kentaro Hanada and Ralph T. Schwarz and Sabrina Sonda and Paul W Denny},
  booktitle={Molecular and biochemical parasitology},
  year={2013}
}
Sphingolipids are essential components of eukaryotic cell membranes, particularly the plasma membrane, and are involved in a diverse array of signal transduction pathways. Mammals produce sphingomyelin (SM) as the primary complex sphingolipid via the well characterised SM synthase. In contrast yeast, plants and some protozoa utilise an evolutionarily related inositol phosphorylceramide (IPC) synthase to synthesise IPC. This activity has no mammalian equivalent and IPC synthase has been proposed… CONTINUE READING