Sphingolipid modulation of angiogenic factor expression in neuroblastoma.

  title={Sphingolipid modulation of angiogenic factor expression in neuroblastoma.},
  author={Mei-Hong Li and Timothy Hla and Fernando Puig Ferrer},
  journal={Cancer prevention research},
  volume={4 8},
Metabolism of sphingolipids into downstream lipid mediators followed by signaling modulates tumor microenvironment and the cancer cells to influence tumor progression. As such, sphingolipid signaling represents a novel way to modulate tumor biology. Neuroblastoma (NB), the most common extracranial solid tumor of childhood, is highly angiogenic and often displays poor prognosis. However, the role of sphingolipid mediators is not known in NB. We found that NB expresses high levels of sphingosine… CONTINUE READING


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