Sphingolipid metabolism and drug resistance in hematological malignancies.


Drug resistance represents a serious barrier to the successful treatment of hematological malignancies. In leukemias, resistance mechanisms that involve membrane-resident proteins belonging to the ABC (ATP-binding cassette) transporter protein family are of particular interest, wherein enhanced expression is often associated with poor prognosis and frequent… (More)


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@article{GouazAndersson2011SphingolipidMA, title={Sphingolipid metabolism and drug resistance in hematological malignancies.}, author={Val{\'e}rie Gouaz{\'e}-Andersson and Myles C. Cabot}, journal={Anti-cancer agents in medicinal chemistry}, year={2011}, volume={11 9}, pages={891-903} }