Sphingolipid-mediated inhibition of apoptotic cell clearance by alveolar macrophages.

@article{Petrusca2010SphingolipidmediatedIO,
  title={Sphingolipid-mediated inhibition of apoptotic cell clearance by alveolar macrophages.},
  author={Daniela N Petrusca and Yuan Zeng Gu and Jeremy J Adamowicz and Natalia I. Rush and Walter Clyde Hubbard and Patricia Ann Smith and Evgeni V. Berdyshev and Konstantin G Birukov and Chao-Hung Lee and Rubin M. Tuder and Homer L Twigg and Robert William Vandivier and Irina Petrache},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 51},
  pages={
          40322-32
        }
}
A decreased clearance of apoptotic cells (efferocytosis) by alveolar macrophages (AM) may contribute to inflammation in emphysema. The up-regulation of ceramides in response to cigarette smoking (CS) has been linked to AM accumulation and increased detection of apoptotic alveolar epithelial and endothelial cells in lung parenchyma. We hypothesized that ceramides inhibit the AM phagocytosis of apoptotic cells. Release of endogenous ceramides via sphingomyelinase or exogenous ceramide treatments… CONTINUE READING
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Role of Sphingolipids in the Pathobiology of Lung Inflammation

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Smoking exposure induces human lung endothelial cell adaptation to apoptotic stress.

  • American journal of respiratory cell and molecular biology
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