Sphingolipid-enriched membrane domains from rat cerebellar granule cells differentiated in culture. A compositional study.

@article{Prinetti2000SphingolipidenrichedMD,
  title={Sphingolipid-enriched membrane domains from rat cerebellar granule cells differentiated in culture. A compositional study.},
  author={Alessandro Prinetti and Vanna Chigorno and Guido Tettamanti and Sandro Sonnino},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 16},
  pages={11658-65}
}
Sphingolipid-enriched membrane domains, characterized by a particular protein and lipid composition, have been detected in a variety of cells. However, limited data are available concerning these domains in neuronal cells. We analyzed the lipid and protein composition of a sphingolipid-enriched membrane fraction prepared from primary rat cerebellar granule cells differentiated in culture. Although the protein content of this fraction was only 1.4% of total cellular protein, 60% of the… CONTINUE READING

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