Spherules derived from Coccidioides posadasii promote human dendritic cell maturation and activation.

@article{Dionne2006SpherulesDF,
  title={Spherules derived from Coccidioides posadasii promote human dendritic cell maturation and activation.},
  author={Sara O. Dionne and Abigail B. Podany and Yvette W. Ruiz and Neil M Ampel and John N. Galgiani and Douglas F. Lake},
  journal={Infection and immunity},
  year={2006},
  volume={74 4},
  pages={2415-22}
}
Previous studies have shown that dendritic cells (DC) pulsed with T27K, an antigenic preparation derived from spherules (of Coccidioides posadasii), activate peripheral blood mononuclear cells (PBMC) from nonimmune subjects as well as from patients with disseminated coccidioidomycosis. In this study, we have assessed the interaction between human DC and C. posadasii spherules in order to better understand the initial response between Coccidioides and the human host. Whole autoclaved spherules… CONTINUE READING
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