Spheroids in radiobiology and photodynamic therapy.

  title={Spheroids in radiobiology and photodynamic therapy.},
  author={C Dubessy and Jean Marie Merlin and Christian Marchal and François Guillemin},
  journal={Critical reviews in oncology/hematology},
  volume={36 2-3},
Spheroids are tridimensional aggregates of tumor cells coming from one or several cell clones. This model, which mimics the micro-tumors structure and some of their properties, shows oxygen, pH and nutrient gradients inducing a necrotic area in the center of the spheroid. Analysis of spheroids, cultured under static or stirred conditions, can be performed on whole spheroids or dissociated spheroids. The spheroids sensitivity to ionizing radiation and photodynamic therapy can be altered by… CONTINUE READING
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