Spheroid formation and differentiation into hepatocyte-like cells of rat mesenchymal stem cell induced by co-culture with liver cells.

@article{Qihao2007SpheroidFA,
  title={Spheroid formation and differentiation into hepatocyte-like cells of rat mesenchymal stem cell induced by co-culture with liver cells.},
  author={Zhang Qihao and Chen Xigu and Cui Guanghui and Zheng Weiwei},
  journal={DNA and cell biology},
  year={2007},
  volume={26 7},
  pages={497-503}
}
Mesenchymal stem cells (MSCs) derived from bone marrow have been shown to differentiate into hepatocytes, which would be an ideal resource for transplantation or artificial liver devices. Here we investigated the efficiency of co-culture system consisting of rat MSCs and adult liver cells to induce differentiation of MSCs into hepatocyte-like cells. Marked MSCs were either co-cultured with freshly isolated liver cells or treated with hepatocyte growth factor (HGF) for 21 days. In co-culture… CONTINUE READING

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