Spheroid-based drug screen: considerations and practical approach

  title={Spheroid-based drug screen: considerations and practical approach},
  author={J. Friedrich and C. Seidel and R. Ebner and L. Kunz-Schughart},
  journal={Nature Protocols},
  • J. Friedrich, C. Seidel, +1 author L. Kunz-Schughart
  • Published 2009
  • Biology, Medicine
  • Nature Protocols
  • Although used in academic research for several decades, 3D culture models have long been regarded expensive, cumbersome and unnecessary in drug development processes. Technical advances, coupled with recent observations showing that gene expression in 3D is much closer to clinical expression profiles than those seen in 2D, have renewed attention and generated hope in the feasibility of maturing organotypic 3D systems to therapy test platforms with greater power to predict clinical efficacies… CONTINUE READING
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