Spheroid-based 3-dimensional culture models: Gene expression and functionality in head and neck cancer.

@article{Schmidt2016Spheroidbased3C,
  title={Spheroid-based 3-dimensional culture models: Gene expression and functionality in head and neck cancer.},
  author={Marianne Schmidt and Claus-J{\"u}rgen Scholz and Christine Polednik and Jeanette Roller},
  journal={Oncology reports},
  year={2016},
  volume={35 4},
  pages={
          2431-40
        }
}
In the present study a panel of 12 head and neck cancer (HNSCC) cell lines were tested for spheroid formation. Since the size and morphology of spheroids is dependent on both cell adhesion and proliferation in the 3-dimensional (3D) context, morphology of HNSCC spheroids was related to expression of E-cadherin and the proliferation marker Ki67. In HNSCC cell lines the formation of tight regular spheroids was dependent on distinct E-cadherin expression levels in monolayer cultures, usually… 
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