Spherical aggregates of beta-amyloid (amylospheroid) show high neurotoxicity and activate tau protein kinase I/glycogen synthase kinase-3beta.

@article{Hoshi2003SphericalAO,
  title={Spherical aggregates of beta-amyloid (amylospheroid) show high neurotoxicity and activate tau protein kinase I/glycogen synthase kinase-3beta.},
  author={Minako M Hoshi and Michio Sato and Shinichiro Matsumoto and Akihiko Noguchi and Kaori Yasutake and Natsuko Yoshida and Kazuki Sato},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 11},
  pages={6370-5}
}
beta-Amyloid (Abeta) acquires toxicity by self-aggregation. To identify and characterize the toxic form(s) of Abeta aggregates, we examined in vitro aggregation conditions by using large quantities of homogenous, chemically synthesized Abeta1-40 peptide. We found that slow rotation of Abeta1-40 solution reproducibly gave self-aggregated Abeta1-40 containing a stable and highly toxic moiety. Examination of the aggregates purified by glycerol-gradient centrifugation by atomic force microscopy and… CONTINUE READING
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