Spherical Nucleic Acid Architecture Can Improve the Efficacy of Polycation-Mediated siRNA Delivery

@inproceedings{Melamed2018SphericalNA,
  title={Spherical Nucleic Acid Architecture Can Improve the Efficacy of Polycation-Mediated siRNA Delivery},
  author={Jilian R Melamed and Nicole L. Kreuzberger and Ritu Goyal and Emily S Day},
  year={2018}
}
Clinical translation of small interfering RNA (siRNA) nanocarriers is hindered by limited knowledge regarding the parameters that regulate interactions between nanocarriers and biological systems. To address this, we investigated the influence of polycation-based nanocarrier architecture on intracellular siRNA delivery. We compared the cellular interactions… CONTINUE READING