Sphere of equivalence--a novel target volume concept for intraoperative radiotherapy using low-energy X rays.


PURPOSE Accelerated partial breast radiotherapy with low-energy photons from a miniature X-ray machine is undergoing a randomized clinical trial (Targeted Intra-operative Radiation Therapy [TARGIT]) in a selected subgroup of patients treated with breast-conserving surgery. The steep radial dose gradient implies reduced tumor cell control with increasing… (More)
DOI: 10.1016/j.ijrobp.2008.08.009


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