Spermine synthase deficiency resulting in X-linked intellectual disability (Snyder-Robinson syndrome).

@article{Schwartz2011SpermineSD,
  title={Spermine synthase deficiency resulting in X-linked intellectual disability (Snyder-Robinson syndrome).},
  author={Charles E. Schwartz and Xaiojing Wang and Roger E Stevenson and Anthony E. Pegg},
  journal={Methods in molecular biology},
  year={2011},
  volume={720},
  pages={
          437-45
        }
}
Polyamines, small positively charged molecules, are vital for cell proliferation and differentiation. They are found ubiquitously in eukaryotic cells. Additionally, they interact with a wide range of other molecules and some membrane associated receptors. Polyamines, spermidine and spermine, are synthesized by two aminopropyltransferases, spermidine synthase and spermine synthase. Recently, mutations in the latter enzyme have been shown to be responsible for an X-linked intellectual disability… CONTINUE READING

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Polyamine analysis by LC-MS.

  • Methods in molecular biology
  • 2011
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