Spermine prevent iron accumulation and depress lipofuscin accumulation in cultured myocardial cells.

@article{Marzabadi1996SperminePI,
  title={Spermine prevent iron accumulation and depress lipofuscin accumulation in cultured myocardial cells.},
  author={Mohammad R Marzabadi and E Lłvaas},
  journal={Free radical biology & medicine},
  year={1996},
  volume={21 3},
  pages={375-81}
}
The present work demonstrates that spermine prevents aging in cultured myocytes exposed to oxidative stress. It is found that physiological levels of spermine reduce lipofuscin accumulation with 20%, and that the antioxidative effect compares with vitamin E. By autometallography we also demonstrate that spermine prevent accumulation of free iron in the… CONTINUE READING