Spermine metabolism and anticancer therapy.

  title={Spermine metabolism and anticancer therapy.},
  author={Roberto Amendola and Manuela Cervelli and Emiliano Fratini and Fabio Polticelli and Davide E Sallustio and Paolo Mariottini},
  journal={Current cancer drug targets},
  volume={9 2},
The natural polyamines (PA), putrescine (PUT), spermidine (SPD) and spermine (SPM) are ubiquitous constituents of eukaryotic cells. The increase of PA in malignant and proliferating cells attracted the interest of scientists during last decades, addressing PA depletion as a new strategy to inhibit cell growth. Selective enzyme inhibitors were developed for decreasing PA metabolism and to act as chemotherapeutic anticancer agents. Indeed, the complexity of the PA homoeostasis overcomes the PA… CONTINUE READING