Spermine inhibits Endoplasmic Reticulum Stress-induced Apoptosis: a New Strategy to Prevent Cardiomyocyte Apoptosis.

@article{Wei2016SpermineIE,
  title={Spermine inhibits Endoplasmic Reticulum Stress-induced Apoptosis: a New Strategy to Prevent Cardiomyocyte Apoptosis.},
  author={Can Wei and Yuehong Wang and Meixiu Li and Hongzhu Li and Xiaoxiao Lu and Hongjiang Shao and Changqing Xu},
  journal={Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology},
  year={2016},
  volume={38 2},
  pages={531-44}
}
BACKGROUND/AIMS Endoplasmic reticulum stress (ERS) plays an important role in the progression of acute myocardial infarction (AMI), in part by mediating apoptosis. Polyamines, including putrescine, spermidine, and spermine, are polycations with anti-oxidative, anti-aging, and cell growth-promoting activities. This study aimed to determine the mechanisms by which spermine protects against ERS-induced apoptosis in rats following AMI. METHODS AND RESULTS AMI was established by ligation of the… CONTINUE READING