Spermine inhibition of monocyte activation and inflammation.

@article{Zhang1999SpermineIO,
  title={Spermine inhibition of monocyte activation and inflammation.},
  author={Minghuang Zhang and Lyudmila V. Borovikova and Hong Wang and Christine M Metz and Kevin J Tracey},
  journal={Molecular medicine},
  year={1999},
  volume={5 9},
  pages={
          595-605
        }
}
The innate immune system functions as a defensive front line against pathogenic invasion, but the proinflammatory products of activated monocytes and macrophages (e.g., TNF and NO) can also injure normal cells. Anti-inflammatory mediators restrain the innate immune response and prevent excessive collateral tissue damage. Spermine, a ubiquitous biogenic polyamine, specifically and reversibly suppresses the synthesis of monocyte proinflammatory cytokines. This may provide a counterregulatory… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 16 references

Poly - amine transport in mammalian cells . An update

CA Haven, JW Olson, SS Arcot
Int . J . Biochem . Cell . Biol . • 1996

Update on the mechanisms of immune suppression of injury and immune modulation

KD Elgert, DG Alleva
World J . Surg . • 1996

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