Spermine inhibition of monocyte activation and inflammation.

  title={Spermine inhibition of monocyte activation and inflammation.},
  author={Minghuang Zhang and Lyudmila V. Borovikova and Hong Wang and Christine M Metz and Kevin J Tracey},
  journal={Molecular medicine},
  volume={5 9},
The innate immune system functions as a defensive front line against pathogenic invasion, but the proinflammatory products of activated monocytes and macrophages (e.g., TNF and NO) can also injure normal cells. Anti-inflammatory mediators restrain the innate immune response and prevent excessive collateral tissue damage. Spermine, a ubiquitous biogenic polyamine, specifically and reversibly suppresses the synthesis of monocyte proinflammatory cytokines. This may provide a counterregulatory… CONTINUE READING


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