Spermine induces maturation of the immature intestinal immune system in neonatal mice.

@article{Steege1997SpermineIM,
  title={Spermine induces maturation of the immature intestinal immune system in neonatal mice.},
  author={Jessica ter Steege and Wim A. Buurman and P. P. Forget},
  journal={Journal of pediatric gastroenterology and nutrition},
  year={1997},
  volume={25 3},
  pages={332-40}
}
BACKGROUND In mice, immunological adaptation of the gut to microbial and nutritional antigens occurs at weaning in parallel with biochemical and morphological maturation. Because oral administration of spermine to neonatal rats has been shown to induce biochemical and morphological maturation, we investigated whether spermine also affects maturation of the mucosal immune system. METHODS Swiss mice 7, 12, and 27 days old were given spermine orally (0.5 mumol/g body weight) during 3 days… CONTINUE READING
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