Spermine differentially regulates the production of interleukin-12 p40 and interleukin-10 and suppresses the release of the T helper 1 cytokine interferon-gamma.

@article{Hask2000SpermineDR,
  title={Spermine differentially regulates the production of interleukin-12 p40 and interleukin-10 and suppresses the release of the T helper 1 cytokine interferon-gamma.},
  author={Gy{\"o}rgy Hask{\'o} and David G. Kuhel and Anita Marton and Zoltan H Nemeth and Edwin A. Deitch and Csaba Szab{\'o}},
  journal={Shock},
  year={2000},
  volume={14 2},
  pages={144-9}
}
Polyamines are endogenous immunomodulatory molecules. Recent studies revealed that polyamines suppress the production of proinflammatory cytokines and nitric oxide. In the present study, we investigated the effect of the polyamines spermine, spermidine, and putrescine on the production of interleukin (IL)-12 p40, IL-10, and interferon (IFN-gamma) in mouse peritoneal macrophages and spleen cell suspensions. Spermine, but not spermidine or putrescine, suppressed, in a concentration-dependent… CONTINUE READING

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