Spermine deficiency in Gy mice caused by deletion of the spermine synthase gene.

@article{Lorenz1998SpermineDI,
  title={Spermine deficiency in Gy mice caused by deletion of the spermine synthase gene.},
  author={Bettina Lorenz and Fiona Francis and Klaus Gempel and Annett Boeddrich and Marcus Josten and Wolfgang Schmahl and Janet Schmidt and Hans Lehrach and Thomas Meitinger and Tim Matthias Strom},
  journal={Human molecular genetics},
  year={1998},
  volume={7 3},
  pages={541-7}
}
Two mouse mutations gyro (Gy) and hypophosphatemia (Hyp) are mouse models for X-linked hypophosphatemic rickets and have been shown to be deleted for the 5' and 3' end of the mouse homolog of PHEX (phosphate regulating gene with homologies to endopeptidases on the X chromosome; formerly called PEX), respectively. In addition to the metabolic disorder observed in Hyp mice, male Gy mice are sterile and show circling behavior and reduced viability. The human SMS (spermine synthase) gene maps… CONTINUE READING
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A gene with homologies to endopeptidases is mutated in patients with X - linked hypophosphatemic rickets

  • T. M. Strom, F. Francis, +4 authors T. Meitinger
  • Nature Genet .
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