Spermine-DNA interactions: a theoretical study.

  title={Spermine-DNA interactions: a theoretical study.},
  author={Burt G. Feuerstein and Nagarajan Pattabiraman and Laurence J. Marton},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={83 16},
Models for the interaction of spermine and DNA were studied by performing conformational energy calculations on spermine and molecular mechanics calculations on major and minor groove complexes of spermine and oligomers of DNA. Docked into the major groove of B-DNA, spermine stabilizes the complex by maximizing interactions between proton acceptors on the… CONTINUE READING