Spermine/spermidine is expressed by retinal glial (Müller) cells and controls distinct K+ channels of their membrane.

@article{Biedermann1998SperminespermidineIE,
  title={Spermine/spermidine is expressed by retinal glial (M{\"u}ller) cells and controls distinct K+ channels of their membrane.},
  author={Bernd Biedermann and Serguei N Skatchkov and Irene Brunk and Andreas Bringmann and Thomas Pannicke and Hans Gert Bernstein and Frank Faude and Angela Germer and R{\"u}diger W Veh and Andreas Reichenbach},
  journal={Glia},
  year={1998},
  volume={23 3},
  pages={209-20}
}
There is recent evidence that polyamines such as spermine (spm) and spermidine (spd) may act as endogenous modulators of the activity of inwardly rectifying K+ channels. This type of K+ channels is abundantly expressed by retinal glial (Müller) cells where they are involved in important glial cell functions such as the clearance of excess extracellular K+ ions. This prompted us to study the following questions, i) do mammalian Müller cells contain endogenous spm/spd?; ii) do Müller cells… CONTINUE READING
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