Spermidine as a target for cancer therapy.

  title={Spermidine as a target for cancer therapy.},
  author={Jingjing Fan and Ziyuan Feng and Ning Chena},
  journal={Pharmacological research},

The Potential Role of Spermine and Its Acetylated Derivative in Human Malignancies

This review summarized the roles of spermine in cancer development and as a diagnostic, prognostic and therapeutic tool in various cancers.

The role of polyamine metabolism in remodeling immune responses and blocking therapy within the tumor immune microenvironment

Recent evidence shows that polyamine metabolism plays essential roles in remodeling the tumor immune microenvironment (TIME), particularly treatment of DFMO, an inhibitor of ODC, alters the immune cell population in the tumor microenvironment.

Research Progress and Potential Applications of Spermidine in Ocular Diseases

This study shows the current landscape of studies on spermidine and its potential to become a promising therapeutic agent to treat ocular diseases: glaucoma, optic nerve injury, age-related macular degeneration, cataracts, dry eye syndrome, and bacterial keratitis.

Immune System, Microbiota, and Microbial Metabolites: The Unresolved Triad in Colorectal Cancer Microenvironment

How dynamics in the gut microbiota, their metabolites, and tumor microenvironment interplays in sporadic and hereditary CRC, modulating tumor progression is discussed.

Nanospermidine in Combination with Nanofenretinide Induces Cell Death in Neuroblastoma Cell Lines

The proven ability of spermidine to activate macrophages and lymphocytes suggests that nanos permidine could inhibit immunosuppression in the tumor environment and suggest it has the potential to become a new approach in cancer treatment.

Common Pathogenetic Mechanisms Underlying Aging and Tumor and Means of Interventions

The underlying pathogenetic mechanisms of aging-related cancers are identified by comparing alterations in the human body caused by aging and the factors that trigger cancers and it is proposed that aging and cancer have common means of intervention.

A Metabolic Model of Intestinal Secretions: The Link between Human Microbiota and Colorectal Cancer Progression

Modulating the gut microbiome could be a promising strategy for the prevention and treatment of CRC by promoting inflammation, cancer progression and cancer prevention by increasing and decreasing certain metabolites such as histamine, glutamine and pyruvate.

Melanoma-Targeted Photodynamic Therapy Based on Hypericin-Loaded Multifunctional P123-Spermine/Folate Micelles

The interpretation of these results suggested that the combination of SM and FA on P123 micelles is the main factor in enhancing the HYP uptake by melanoma cells, consequently leading to its photoinactivation.

Genotype and Maturity Stage Affect the Content and Composition of Polyamines in Tomato—Possible Relations to Plant and Human Health

Polyamines (PAs) are molecules affecting several physiological characteristics in all living organisms with cell protective effects, thereby impacting plant and human health. Here, we used



Targeting polyamine metabolism for cancer therapy and prevention.

The goal of this article is to review the latest findings in the field that demonstrate the potential utility of targeting the metabolism and function of polyamines as strategies for both chemotherapy and, possibly more importantly, chemoprevention.

Molecular Basis of the ‘Anti-Aging' Effect of Spermidine and Other Natural Polyamines - A Mini-Review

An up-to-date overview of the so far identified mechanisms of action of spermidine and other polyamines on aging is presented and it is suggested that the main pathway used by sperMidine to trigger its effects is the MAPK pathway.

Spermidine‑induced growth inhibition and apoptosis via autophagic activation in cervical cancer.

A novel function for spermidine is revealed in inhibiting cellular proliferation and inducing apoptosis of HeLa cells by activating autophagy, which may have important implications for the use of sperMidine in cervical cancer therapy.

Polyamines and Their Metabolites as Diagnostic Markers of Human Diseases

Levels of protein-conjuagated acrolein (PC-Acro) and polyamine oxidizing enzymes were increased in the locus of brain infarction and in plasma in a mouse model of stroke and also in the plasma of stroke patients.

Polyamines and cancer: implications for chemotherapy and chemoprevention

Recent advances made in the polyamine field are described and the roles of polyamines and polyamine metabolism in neoplasia are focused on through a discussion of the current animal models for thepolyamine pathway, chemotherapeutic strategies that target the polyamines pathway, and chemotherAPEutic clinical trials for polyamine pathway-specific drugs and ongoing clinical trials targeting polyamine biosynthesis.

The mechanisms by which polyamines accelerate tumor spread

  • K. Soda
  • Biology
    Journal of experimental & clinical cancer research : CR
  • 2011
Investigations revealed that increased polyamine availability enhances the capability of cancer cells to invade and metastasize to new tissues while diminishing immune cells' anti-tumor immune functions.

Maize polyamine oxidase in the presence of spermine/spermidine induces the apoptosis of LoVo human colon adenocarcinoma cells

It was found that treatment with ZmPAO and spermine markedly reduced mitochondrial membrane potential in the LoVo DX cells, in agreement with the results of cell viability and apoptosis assays, and the dysregulation of polyamine metabolism in tumor cells may be a potential therapeutic target.

Targeting polyamine biosynthetic pathway through RNAi causes the abrogation of MCF 7 breast cancer cell line

RNAi-mediated reduction in the expression of PA biosynthesis genes resulted in distorted cell morphology, reduced cancer cell viability, and migration characteristic, suggesting that the targeting polyamine biosynthesis through RNAi approach could be a promising strategy for breast cancer therapy and might be extended for therapy of other cancers.

Polyamine metabolism and cancer: treatments, challenges and opportunities

New insights into molecular mechanisms that link the dysregulation of polyamine metabolism with carcinogenesis and strategies for targeting this pathway for cancer therapy are discussed.