Spermidine: A novel autophagy inducer and longevity elixir

@article{Madeo2010SpermidineAN,
  title={Spermidine: A novel autophagy inducer and longevity elixir},
  author={Frank Madeo and Tobias Eisenberg and Sabrina B{\"u}ttner and Christoph Ruckenstuhl and Guido Kroemer},
  journal={Autophagy},
  year={2010},
  volume={6},
  pages={14 - 160 - 162}
}
Spermidine is a ubiquitous polycation that is synthesized from putrescine and serves as a precursor of spermine. Putrescine, spermidine and spermine all are polyamines that participate in multiple known and unknown biological processes. Exogenous supply of spermidine prolongs the life span of several model organisms including yeast (Saccharomyces cerevisiae), nematodes (Caenorhabditis elegans) and flies (Drosophila melanogaster) and significantly reduces age-related oxidative protein damage in… 

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