Spermidine/spermine-N(1)-acetyltransferase: a key metabolic regulator.

@article{Pegg2008SpermidinespermineN1acetyltransferase,
  title={Spermidine/spermine-N(1)-acetyltransferase: a key metabolic regulator.},
  author={Anthony E. Pegg},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2008},
  volume={294 6},
  pages={
          E995-1010
        }
}
  • A. Pegg
  • Published 1 June 2008
  • Biology
  • American journal of physiology. Endocrinology and metabolism
Spermidine/spermine-N(1)-acetyltransferase (SSAT) regulates cellular polyamine content. Its acetylated products are either excreted from the cell or oxidized by acetylpolyamine oxidase. Since polyamines play critical roles in normal and neoplastic growth and in ion channel regulation, SSAT is a key enzyme in these processes. SSAT is very highly regulated. Its content is adjusted in response to alterations in polyamine content to maintain polyamine homeostasis. Certain polyamine analogs can… 

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