Spermatogonial stem cell self-renewal and development.

@article{KanatsuShinohara2013SpermatogonialSC,
  title={Spermatogonial stem cell self-renewal and development.},
  author={Mito Kanatsu-Shinohara and Takashi Shinohara},
  journal={Annual review of cell and developmental biology},
  year={2013},
  volume={29},
  pages={163-87}
}
Spermatogenesis originates from spermatogonial stem cells (SSCs). Development of the spermatogonial transplantation technique in 1994 provided the first functional assay to characterize SSCs. In 2000, glial cell line-derived neurotrophic factor was identified as a SSC self-renewal factor. This discovery not only provided a clue to understand SSC self-renewing mechanisms but also made it possible to derive germline stem (GS) cell cultures in 2003. In vitro culture of GS cells demonstrated their… CONTINUE READING

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