Spermatogonial cytogenetic toxicity of vincristine and its transmission in the germline cells of Swiss mice.

Abstract

We tested the anticancer drug vincristine sulfate (VCR) and cyclophosphamide for their cytogenetic toxic effects on spermatogonia in Swiss mice, and we assessed the possible transmission of such effects in the germline cells. Spermatogonial metaphase chromosome aberration study, primary spermatocytic chromosome analysis, and sperm morphology assay were… (More)

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