Spermatogenetic but not immunological defects in mice lacking the τCstF-64 polyadenylation protein.

@article{Hockert2011SpermatogeneticBN,
  title={Spermatogenetic but not immunological defects in mice lacking the τCstF-64 polyadenylation protein.},
  author={Kathy Jo Hockert and Kathleen Martincic and S.M.L. Chamindrani Mendis-Handagama and Lisa Ann Borghesi and Christine Milcarek and Brinda Rani Dass and C C MacDonald},
  journal={Journal of reproductive immunology},
  year={2011},
  volume={89 1},
  pages={
          26-37
        }
}
Alternative polyadenylation controls expression of genes in many tissues including immune cells and male germ cells. The τCstF-64 polyadenylation protein is expressed in both cell types, and we previously showed that Cstf2t, the gene encoding τCstF-64 was necessary for spermatogenesis and fertilization. Here we examine consequences of τCstF-64 loss in both germ cells and immune cells. Spermatozoa from Cstf2t null mutant (Cstf2t(-/-)) mice of ages ranging from 60 to 108 days postpartum exhibited… CONTINUE READING
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