Spermatogenesis by Sisyphus: proliferating stem germ cells fail to repopulate the testis after 'irreversible' injury.

@article{Boekelheide2001SpermatogenesisBS,
  title={Spermatogenesis by Sisyphus: proliferating stem germ cells fail to repopulate the testis after 'irreversible' injury.},
  author={Kim Boekelheide and Heidi A Schoenfeld},
  journal={Advances in experimental medicine and biology},
  year={2001},
  volume={500},
  pages={421-8}
}
2,5-Hexanedione is the toxic metabolite resulting from oxidation of the commonly used solvents n-hexane and methyl n-butyl ketone. Exposure to 2,5-hexanedione or its precursors results in a slowly progressive peripheral polyneuropathy and testicular injury. The chemical basis of the injury involves reaction of 2,5-hexanedione with protein amines, such as… CONTINUE READING